Research Proposal (non-funded; 2015) Background and Significance. Corticotropin releasing factor (CRF) may play a critical role in the motivational effects of continued alcohol abuse [1]. While CRF has been intensively studied for its function in stress and anxiety within the HPA axis, it its function in key limbic areas position this peptide to regulate affective … Continue reading The role of corticotropin releasing factor in the enhancement of conditioned fear in alcohol-dependent rats. →