What are the various psychological effects of COVID-19 infection? How does the coronavirus produce such effects? And what can we learn about coronaviruses and brain function in general? To better understand the true impact of COVID-19, it is vital that we examine the acute and long-term effects that infection has on mental health. In this essay, I describe the various acute and long-term psychological, psychiatric, and neurological symptoms associated with COVID-19, outline neuroanatomical findings in infected patients that may underlie these symptoms, and discuss what we can learn about psychological disorders through the lens of COVID-19.